The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

NOD2 is essential for antimicrobial innate immunity and tissue homeostasis, but require tight regulation to avert pathology. A focal point of NOD2 signaling is RIP2, which upon polyubiquitination nucleates the NOD2:RIP2 complex, enabling signaling events leading to inflammation, yet the precise natu...

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Detalles Bibliográficos
Autores principales: Panda, Swarupa, Gekara, Nelson O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220254/
https://www.ncbi.nlm.nih.gov/pubmed/30405132
http://dx.doi.org/10.1038/s41467-018-07016-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220254/
https://www.ncbi.nlm.nih.gov/pubmed/30405132
http://dx.doi.org/10.1038/s41467-018-07016-0

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