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A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease
A major hallmark of Alzheimer's disease (AD) is the deposition of amyloid‐beta (Aβ) plaques in the brain. Sequential cleavage of amyloid precursor protein by BACE1 and γ‐secretase generates Aβ. Thus, BACE1 is an attractive AD drug target. Although many BACE1 inhibitors have advanced to clinical...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220261/ https://www.ncbi.nlm.nih.gov/pubmed/30322841 http://dx.doi.org/10.15252/emmm.201809717 |