High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associated TREM2 variants to various forms of Aβ and APOE in mu...

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Detalles Bibliográficos
Autores principales: Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220267/
https://www.ncbi.nlm.nih.gov/pubmed/30341064
http://dx.doi.org/10.15252/emmm.201809027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220267/
https://www.ncbi.nlm.nih.gov/pubmed/30341064
http://dx.doi.org/10.15252/emmm.201809027

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