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Epithelial cells release adenosine to promote local TNF production in response to polarity disruption
Disruption of epithelial integrity contributes to chronic inflammatory disorders through persistent activation of stress signalling. Here we uncover a mechanism whereby disruption of apico-basal polarity promotes stress signalling. We show that depletion of Scribbled (Scrib), a baso-lateral determin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220285/ https://www.ncbi.nlm.nih.gov/pubmed/30405122 http://dx.doi.org/10.1038/s41467-018-07114-z |