Synthesis and Preclinical Evaluation of the First Carbon-11 Labeled PET Tracers Targeting Substance P(1–7)

[Image: see text] Two potent SP(1–7) peptidomimetics have been successfully radiolabeled via [(11)C]CO(2)-fixation with excellent yields, purity, and molar activity. l-[(11)C]SP(1–7)-peptidomimetic exhibited promising ex vivo biodistribution profile. Metabolite analysis showed that l-[(11)C]SP(1–7)-...

Descripción completa

Detalles Bibliográficos
Autores principales: Pekošak, Aleksandra, Bulc, Janez Ž., Korat, Špela, Schuit, Robert C., Kooijman, Esther, Vos, Ricardo, Rongen, Marissa, Verlaan, Mariska, Takkenkamp, Kevin, Beaino, Wissam, Poot, Alex J., Windhorst, Albert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220361/
https://www.ncbi.nlm.nih.gov/pubmed/30335399
http://dx.doi.org/10.1021/acs.molpharmaceut.8b00518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220361/
https://www.ncbi.nlm.nih.gov/pubmed/30335399
http://dx.doi.org/10.1021/acs.molpharmaceut.8b00518

Ejemplares similares