Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

[Image: see text] Top-down proteomics is an emerging analytical strategy to characterize combinatorial protein post-translational modifications (PTMs). However, sample complexity and small mass differences between chemically closely related proteoforms often limit the resolution attainable by separa...

Descripción completa

Detalles Bibliográficos
Autores principales: Gargano, Andrea F. G., Shaw, Jared B., Zhou, Mowei, Wilkins, Christopher S., Fillmore, Thomas L., Moore, Ronald J., Somsen, Govert W., Paša-Tolić, Ljiljana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220366/
https://www.ncbi.nlm.nih.gov/pubmed/30226781
http://dx.doi.org/10.1021/acs.jproteome.8b00458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220366/
https://www.ncbi.nlm.nih.gov/pubmed/30226781
http://dx.doi.org/10.1021/acs.jproteome.8b00458

Ejemplares similares