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Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

[Image: see text] Top-down proteomics is an emerging analytical strategy to characterize combinatorial protein post-translational modifications (PTMs). However, sample complexity and small mass differences between chemically closely related proteoforms often limit the resolution attainable by separa...

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Detalles Bibliográficos
Autores principales:	Gargano, Andrea F. G., Shaw, Jared B., Zhou, Mowei, Wilkins, Christopher S., Fillmore, Thomas L., Moore, Ronald J., Somsen, Govert W., Paša-Tolić, Ljiljana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220366/ https://www.ncbi.nlm.nih.gov/pubmed/30226781 http://dx.doi.org/10.1021/acs.jproteome.8b00458

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