Cargando…

Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

BACKGROUND: Causal associations between microglia activation and β-amyloid (Aβ) accumulation during the progression of Alzheimer’s disease (AD) remain a matter of controversy. Therefore, we used longitudinal dual tracer in vivo small animal positron emission tomography (μPET) imaging to resolve the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blume, Tanja, Focke, Carola, Peters, Finn, Deussing, Maximilian, Albert, Nathalie L., Lindner, Simon, Gildehaus, Franz-Josef, von Ungern-Sternberg, Barbara, Ozmen, Laurence, Baumann, Karlheinz, Bartenstein, Peter, Rominger, Axel, Herms, Jochen, Brendel, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220478/ https://www.ncbi.nlm.nih.gov/pubmed/30400912 http://dx.doi.org/10.1186/s12974-018-1347-6

Ejemplares similares

Data on specificity of [(18)F]GE180 uptake for TSPO expression in rodent brain and myocardium
por: Deussing, Maximilian, et al.
Publicado: (2018)

Comparison of (18)F-T807 and (18)F-THK5117 PET in a Mouse Model of Tau Pathology
por: Brendel, Matthias, et al.
Publicado: (2018)

Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis
por: Brendel, Matthias, et al.
Publicado: (2017)

Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation
por: Biechele, Gloria, et al.
Publicado: (2021)

Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition
por: Blume, Tanja, et al.
Publicado: (2022)

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice
por: Overhoff, Felix, et al.
Publicado: (2016)

[(18)F]MPPF and [(18)F]FDG μPET imaging in rats: impact of transport and restraint stress
por: Buchecker, Verena, et al.
Publicado: (2020)

Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases
por: Biechele, Gloria, et al.
Publicado: (2020)

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
por: Brendel, Matthias, et al.
Publicado: (2019)

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
por: Brendel, Matthias, et al.
Publicado: (2018)

Longitudinal Studies on Alzheimer Disease Mouse Models with Multiple Tracer PET/CT: Application of Reduction and Refinement Principles in Daily Practice to Safeguard Animal Welfare during Progressive Aging
por: Palumbo, Giovanna, et al.
Publicado: (2023)

Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
por: Eckenweber, Florian, et al.
Publicado: (2020)

Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease
por: Biechele, Gloria, et al.
Publicado: (2022)

Cross-Sectional Comparison of Small Animal [(18)F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models
por: Brendel, Matthias, et al.
Publicado: (2015)

Expression of Translocator Protein and [18F]-GE180 Ligand Uptake in Multiple Sclerosis Animal Models
por: Nack, Anne, et al.
Publicado: (2019)

Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment
por: Brendel, M, et al.
Publicado: (2015)

Assessment of synaptic loss in mouse models of β-amyloid and tau pathology using [(18)F]UCB-H PET imaging
por: Vogler, Letizia, et al.
Publicado: (2023)

Long-Term Pioglitazone Treatment Has No Significant Impact on Microglial Activation and Tau Pathology in P301S Mice
por: Kunze, Lea Helena, et al.
Publicado: (2023)

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
por: Götzl, Julia K, et al.
Publicado: (2019)

Perfusion-Phase [(18)F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration
por: Brendel, Matthias, et al.
Publicado: (2017)

Microfluidics: A Groundbreaking Technology for PET Tracer Production?
por: Rensch, Christian, et al.
Publicado: (2013)

β-secretase inhibition prevents structural spine plasticity deficits in App(NL-G-F) mice
por: Blume, Tanja, et al.
Publicado: (2022)

Monitoring of Tumor Growth with [(18)F]-FET PET in a Mouse Model of Glioblastoma: SUV Measurements and Volumetric Approaches
por: Holzgreve, Adrien, et al.
Publicado: (2016)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

Molecular imaging of cardiac CXCR4 expression in a mouse model of acute myocardial infarction using a novel (68)Ga-mCXCL12 PET tracer
por: Zacherl, Mathias Johannes, et al.
Publicado: (2020)

Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects()()
por: Ewers, Michael, et al.
Publicado: (2013)

Preliminary experience with dosimetry, response and patient reported outcome after (177)Lu-PSMA-617 therapy for metastatic castration-resistant prostate cancer
por: Fendler, Wolfgang P., et al.
Publicado: (2016)

Di-μ-chlorido-bis{[μ-1,8-bis(diisopropylphosphanyl)-9,10-dihydro-9,10-ethanoanthracene-κ(2) P:P′]-μ-chlorido-μ-methylidene-dipalladium(II)} tetrahydrofuran pentasolvate
por: Schnetz, Thomas, et al.
Publicado: (2010)

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation
por: Jung, Christian K. E., et al.
Publicado: (2015)

Identification of brain regions predicting epileptogenesis by serial [(18)F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy
por: Russmann, Vera, et al.
Publicado: (2017)

Pediatric Airway Management in Times of COVID-19—a Review of the Evidence and Controversies
por: Matava, Clyde T, et al.
Publicado: (2021)

The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation
por: von Mücke-Heim, Iven-Alex, et al.
Publicado: (2023)

Paediatric Medicinal Formulation Development: Utilising Human Taste Panels and Incorporating Their Data into Machine Learning Training
por: Yoo, Okhee, et al.
Publicado: (2023)

(18)F-FET PET Uptake Characteristics of Long-Term IDH-Wildtype Diffuse Glioma Survivors
por: Mittlmeier, Lena M., et al.
Publicado: (2021)

Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy
por: Finze, Anika, et al.
Publicado: (2022)

Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease
por: von Ungern-Sternberg, Saskia N. I., et al.
Publicado: (2018)

N95 Masks to Protect Health Care Workers: Is the New Fast Fit-Test Protocol Cutting Corners?
por: Regli, Adrian, et al.
Publicado: (2022)

Identification of the allosteric P2X(7) receptor antagonist [(11)C]SMW139 as a PET tracer of microglial activation
por: Janssen, Bieneke, et al.
Publicado: (2018)

Fox dietary ecology as a tracer of human impact on Pleistocene ecosystems
por: Baumann, Chris, et al.
Publicado: (2020)

Isotopic Tracers
Publicado: (1955)

Cannot write session to /tmp/vufind_sessions/sess_cfkggnjmahtrmgeju3rk9q4gj7