Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell

BACKGROUND: Cholangiocarcinoma (CCA) is a form of cancer that easily aggress to contiguous structures. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) are increased in majority species of cancers and suppress tumor progression by blocking VEGF/VEGFR2. Apatinib is a highly sele...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Manping, Huang, Bin, Li, Guowen, Zeng, Sainan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220519/
https://www.ncbi.nlm.nih.gov/pubmed/30400838
http://dx.doi.org/10.1186/s12876-018-0870-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220519/
https://www.ncbi.nlm.nih.gov/pubmed/30400838
http://dx.doi.org/10.1186/s12876-018-0870-3

Ejemplares similares