Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling

A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp(3))–C(sp(2)) and C(sp(2))–C(sp(2)) couplings and is tole...

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Detalles Bibliográficos
Autores principales: Cao, Qun, Howard, Joseph L., Wheatley, Emilie, Browne, Duncan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220771/
https://www.ncbi.nlm.nih.gov/pubmed/30015403
http://dx.doi.org/10.1002/anie.201806480
Descripción
Sumario:A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp(3))–C(sp(2)) and C(sp(2))–C(sp(2)) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.

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