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Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells

The aberrant misfolding and subsequent conversion of monomeric protein into amyloid aggregates characterises many neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. These aggregates are highly heterogeneous in structure, generally of low abundance and typically sm...

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Detalles Bibliográficos
Autores principales: Whiten, Daniel R., Zuo, Yukun, Calo, Laura, Choi, Minee‐Liane, De, Suman, Flagmeier, Patrick, Wirthensohn, David C., Kundel, Franziska, Ranasinghe, Rohan T., Sanchez, Santiago E., Athauda, Dilan, Lee, Steven F., Dobson, Christopher M., Gandhi, Sonia, Spillantini, Maria‐Grazia, Klenerman, David, Horrocks, Mathew H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220870/
https://www.ncbi.nlm.nih.gov/pubmed/30051958
http://dx.doi.org/10.1002/cbic.201800209