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Modified Peptide Inhibitors of the Keap1–Nrf2 Protein–Protein Interaction Incorporating Unnatural Amino Acids

Noncovalent inhibitors of the Keap1–Nrf2 protein–protein interaction (PPI) have therapeutic potential in a range of disease states including neurodegenerative diseases (Parkinson's and Alzheimer's diseases), chronic obstructive pulmonary disease and various inflammatory conditions. By stal...

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Detalles Bibliográficos
Autores principales: Georgakopoulos, Nikolaos D., Talapatra, Sandeep K., Gatliff, Jemma, Kozielski, Frank, Wells, Geoff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220877/
https://www.ncbi.nlm.nih.gov/pubmed/29927029
http://dx.doi.org/10.1002/cbic.201800170