On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin

A library of mannose‐ and fucose‐based glycomimetics was synthesized and screened in a microarray format against a set of C‐type lectin receptors (CLRs) that included DC‐SIGN, DC‐SIGNR, langerin, and dectin‐2. Glycomimetic ligands able to interact with dectin‐2 were identified for the first time. Co...

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Detalles Bibliográficos
Autores principales: Medve, Laura, Achilli, Silvia, Serna, Sonia, Zuccotto, Fabio, Varga, Norbert, Thépaut, Michel, Civera, Monica, Vivès, Corinne, Fieschi, Franck, Reichardt, Niels, Bernardi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220942/
https://www.ncbi.nlm.nih.gov/pubmed/29975429
http://dx.doi.org/10.1002/chem.201802577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220942/
https://www.ncbi.nlm.nih.gov/pubmed/29975429
http://dx.doi.org/10.1002/chem.201802577

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