On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin

A library of mannose‐ and fucose‐based glycomimetics was synthesized and screened in a microarray format against a set of C‐type lectin receptors (CLRs) that included DC‐SIGN, DC‐SIGNR, langerin, and dectin‐2. Glycomimetic ligands able to interact with dectin‐2 were identified for the first time. Co...

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Autores principales: Medve, Laura, Achilli, Silvia, Serna, Sonia, Zuccotto, Fabio, Varga, Norbert, Thépaut, Michel, Civera, Monica, Vivès, Corinne, Fieschi, Franck, Reichardt, Niels, Bernardi, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220942/
https://www.ncbi.nlm.nih.gov/pubmed/29975429
http://dx.doi.org/10.1002/chem.201802577
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author Medve, Laura
Achilli, Silvia
Serna, Sonia
Zuccotto, Fabio
Varga, Norbert
Thépaut, Michel
Civera, Monica
Vivès, Corinne
Fieschi, Franck
Reichardt, Niels
Bernardi, Anna
author_facet Medve, Laura
Achilli, Silvia
Serna, Sonia
Zuccotto, Fabio
Varga, Norbert
Thépaut, Michel
Civera, Monica
Vivès, Corinne
Fieschi, Franck
Reichardt, Niels
Bernardi, Anna
author_sort Medve, Laura
collection PubMed
description A library of mannose‐ and fucose‐based glycomimetics was synthesized and screened in a microarray format against a set of C‐type lectin receptors (CLRs) that included DC‐SIGN, DC‐SIGNR, langerin, and dectin‐2. Glycomimetic ligands able to interact with dectin‐2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
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spelling pubmed-62209422018-11-15 On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin Medve, Laura Achilli, Silvia Serna, Sonia Zuccotto, Fabio Varga, Norbert Thépaut, Michel Civera, Monica Vivès, Corinne Fieschi, Franck Reichardt, Niels Bernardi, Anna Chemistry Full Papers A library of mannose‐ and fucose‐based glycomimetics was synthesized and screened in a microarray format against a set of C‐type lectin receptors (CLRs) that included DC‐SIGN, DC‐SIGNR, langerin, and dectin‐2. Glycomimetic ligands able to interact with dectin‐2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed. John Wiley and Sons Inc. 2018-09-03 2018-09-25 /pmc/articles/PMC6220942/ /pubmed/29975429 http://dx.doi.org/10.1002/chem.201802577 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Medve, Laura
Achilli, Silvia
Serna, Sonia
Zuccotto, Fabio
Varga, Norbert
Thépaut, Michel
Civera, Monica
Vivès, Corinne
Fieschi, Franck
Reichardt, Niels
Bernardi, Anna
On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title_full On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title_fullStr On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title_full_unstemmed On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title_short On‐Chip Screening of a Glycomimetic Library with C‐Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin‐2 over DC‐SIGN/R and Langerin
title_sort on‐chip screening of a glycomimetic library with c‐type lectins reveals structural features responsible for preferential binding of dectin‐2 over dc‐sign/r and langerin
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220942/
https://www.ncbi.nlm.nih.gov/pubmed/29975429
http://dx.doi.org/10.1002/chem.201802577
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