The Lupus‐Associated Fcγ Receptor IIb–I232T Polymorphism Results in Impairment in the Negative Selection of Low‐Affinity Germinal Center B Cells Via c‐Abl in Mice

OBJECTIVE: Fcγ receptor IIb (FcγRIIb) is an essential negative regulator of B cells that blocks B cell receptor (BCR) signaling and triggers c‐Abl–dependent apoptosis of B cells. FcγRIIb‐deficient mice display splenomegaly with expansion of B cells, leading to lupus. FcγRIIb‐I232T is a hypofunctiona...

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Detalles Bibliográficos
Autores principales: Jhou, Jyun‐Pei, Yu, I‐Shing, Hwai, Haw, Chen, Chih‐Shan, Chen, Pei‐Lung, Tzeng, Shiang‐Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Autoimmunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221021/
https://www.ncbi.nlm.nih.gov/pubmed/29774664
http://dx.doi.org/10.1002/art.40555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221021/
https://www.ncbi.nlm.nih.gov/pubmed/29774664
http://dx.doi.org/10.1002/art.40555

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