Superior protein titers in half the fermentation time: Promoter and process engineering for the glucose‐regulated GTH1 promoter of Pichia pastoris

Protein production in Pichia pastoris is often based on the methanol‐inducible P (AOX1) promoter which drives the expression of the target gene. The use of methanol has major drawbacks, so there is a demand for alternative promoters with good induction properties such as the glucose‐regulated P (GTH...

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Detalles Bibliográficos
Autores principales: Prielhofer, Roland, Reichinger, Michaela, Wagner, Nina, Claes, Katrien, Kiziak, Christoph, Gasser, Brigitte, Mattanovich, Diethard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221138/
https://www.ncbi.nlm.nih.gov/pubmed/30016537
http://dx.doi.org/10.1002/bit.26800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221138/
https://www.ncbi.nlm.nih.gov/pubmed/30016537
http://dx.doi.org/10.1002/bit.26800

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