Cargando…

Endothelial Cell–Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature

OBJECTIVE—: Blood-CNS (central nervous system) barrier defects are implicated in retinopathies, neurodegenerative diseases, stroke, and epilepsy, yet, the pathological mechanisms downstream of barrier defects remain incompletely understood. Blood-retina barrier (BRB) formation and retinal angiogenes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Chi, Lai, Maria B., Pedler, Michelle G., Johnson, Verity, Adams, Ralf H., Petrash, J. Mark, Chen, Zhe, Junge, Harald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2018
Materias:	Basic Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221394/ https://www.ncbi.nlm.nih.gov/pubmed/30354230 http://dx.doi.org/10.1161/ATVBAHA.118.311689

Ejemplares similares

Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins
por: Matthews, Alexandra L., et al.
Publicado: (2017)

Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis
por: Yaseen, Ibrahim H., et al.
Publicado: (2017)

ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration
por: Reyat, Jasmeet S., et al.
Publicado: (2017)

Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains
por: Protty, Majd B., et al.
Publicado: (2008)

Regulation of Leukocytes by TspanC8 Tetraspanins and the “Molecular Scissor” ADAM10
por: Matthews, Alexandra L., et al.
Publicado: (2018)

Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
por: Bonnet, Mathilde, et al.
Publicado: (2019)

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
por: Harrison, Neale, et al.
Publicado: (2021)

The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex
por: Moretto, Edoardo, et al.
Publicado: (2023)

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation
por: Haining, Elizabeth J., et al.
Publicado: (2016)

Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer
por: Maisonial-Besset, Aurelie, et al.
Publicado: (2017)

TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
por: Eschenbrenner, Etienne, et al.
Publicado: (2019)

Impaired Expression of Tetraspanin 32 (TSPAN32) in Memory T Cells of Patients with Multiple Sclerosis
por: Basile, Maria Sofia, et al.
Publicado: (2020)

Modulation of Tetraspanin 32 (TSPAN32) Expression in T Cell-Mediated Immune Responses and in Multiple Sclerosis
por: Lombardo, Salvo Danilo, et al.
Publicado: (2019)

The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity
por: Zhu, Yingying, et al.
Publicado: (2023)

Involvement of the Tetraspanin 2 (TSPAN2) Gene in Migraine: A Case-Control Study in Han Chinese
por: Fang, Jie, et al.
Publicado: (2018)

The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function
por: Liu, Zhiyu, et al.
Publicado: (2022)

Antibody targeting TSPAN12/β-catenin signaling in vasoproliferative retinopathy
por: Bucher, Felicitas, et al.
Publicado: (2017)

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
por: Dornier, Emmanuel, et al.
Publicado: (2012)

The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding
por: Yue, Shijing, et al.
Publicado: (2014)

Multi-factorial modulation of colorectal carcinoma cells motility – partial coordination by the tetraspanin Co-029/tspan8
por: Zhu, Yingying, et al.
Publicado: (2017)

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS
por: Noy, Peter J., et al.
Publicado: (2016)

Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes
por: Yang, Huiqin, et al.
Publicado: (2011)

Novel mutations in the TSPAN12 gene in Chinese patients with familial exudative vitreoretinopathy
por: Xu, Yu, et al.
Publicado: (2014)

TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
por: Ji, Guohua, et al.
Publicado: (2019)

Correction: Antibody targeting TSPAN12/β-catenin signaling in vasoproliferative retinopathy
por: Bucher, Felicitas, et al.
Publicado: (2018)

Correction: TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
por: Dornier, Emmanuel, et al.
Publicado: (2016)

A Positive Tetraspanin 8 (TSPAN8)/β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells
por: Zhan, Zhengyu, et al.
Publicado: (2019)

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization
por: Jouannet, Stéphanie, et al.
Publicado: (2015)

A novel frameshift variant in the TSPAN12 gene causes autosomal dominant FEVR
por: Peng, Li, et al.
Publicado: (2022)

Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway
por: Wu, Yange, et al.
Publicado: (2021)

Mutation spectrum of the FZD-4, TSPAN12 AND ZNF408 genes in Indian FEVR patients
por: Musada, Ganeswara Rao, et al.
Publicado: (2016)

Ring finger protein 152-dependent degradation of TSPAN12 suppresses hepatocellular carcinoma progression
por: Wan, Jian, et al.
Publicado: (2021)

Identification of Five Novel Variants in the TSPAN12 Gene in Chinese Families With Familial Exudative Vitreoretinopathy
por: Wang, You, et al.
Publicado: (2023)

Tspan8 and Tspan8/CD151 knockout mice unravel the contribution of tumor and host exosomes to tumor progression
por: Zhao, Kun, et al.
Publicado: (2018)

TSPAN12 is overexpressed in NSCLC via p53 inhibition and promotes NSCLC cell growth in vitro and in vivo
por: Hu, Zhongwu, et al.
Publicado: (2018)

Familial exudative retinopathy TSPAN12 positive presenting as bilateral retinal stalks: late structural and functional findings
por: Amorelli, Giulia M., et al.
Publicado: (2019)

Detection of FZD4, LRP5 and TSPAN12 Genes Variants in Malay Premature Babies with Retinopathy of Prematurity
por: Mohd Khair, Siti Zulaikha Nashwa, et al.
Publicado: (2019)

DERMAL VASCULATURE IN PSORIASIS AND PSORIASIFORM DERMATITIS: A MORPHOMETRIC STUDY
por: Gupta, Shilpa, et al.
Publicado: (2011)

Prostaglandin analog effects on cerebrospinal fluid reabsorption via nasal mucosa
por: Pedler, Michelle G., et al.
Publicado: (2021)

Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence
por: Schreyer, Laura, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4qhe6otf3332nf6rfmtaa8dph8