Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

Human FACT (facilitates chromatin transcription) is a multifunctional protein complex that has histone chaperone activity and facilitates nucleosome survival and transcription through chromatin. Anticancer drugs curaxins induce FACT trapping on chromatin of cancer cells (c-trapping), but the mechani...

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Detalles Bibliográficos
Autores principales: Chang, Han-Wen, Valieva, Maria E., Safina, Alfiya, Chereji, Răzvan V., Wang, Jianmin, Kulaeva, Olga I., Morozov, Alexandre V., Kirpichnikov, Mikhail P., Feofanov, Alexey V., Gurova, Katerina V., Studitsky, Vasily M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221510/
https://www.ncbi.nlm.nih.gov/pubmed/30417101
http://dx.doi.org/10.1126/sciadv.aav2131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221510/
https://www.ncbi.nlm.nih.gov/pubmed/30417101
http://dx.doi.org/10.1126/sciadv.aav2131

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