Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and human G1-checkpoint-deficient cells: reduction of...

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Detalles Bibliográficos
Autores principales: Benedict, Bente, van Harn, Tanja, Dekker, Marleen, Hermsen, Simone, Kucukosmanoglu, Asli, Pieters, Wietske, Delzenne-Goette, Elly, Dorsman, Josephine C, Petermann, Eva, Foijer, Floris, te Riele, Hein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221544/
https://www.ncbi.nlm.nih.gov/pubmed/30322449
http://dx.doi.org/10.7554/eLife.37868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221544/
https://www.ncbi.nlm.nih.gov/pubmed/30322449
http://dx.doi.org/10.7554/eLife.37868

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