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Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and human G1-checkpoint-deficient cells: reduction of...
Autores principales: | Benedict, Bente, van Harn, Tanja, Dekker, Marleen, Hermsen, Simone, Kucukosmanoglu, Asli, Pieters, Wietske, Delzenne-Goette, Elly, Dorsman, Josephine C, Petermann, Eva, Foijer, Floris, te Riele, Hein |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221544/ https://www.ncbi.nlm.nih.gov/pubmed/30322449 http://dx.doi.org/10.7554/eLife.37868 |
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