HDAC3 Inhibition Promotes Alternative Activation of Macrophages but Does Not Affect Functional Recovery after Spinal Cord Injury

After spinal cord injury (SCI), monocyte derived macrophages play a detrimental role. Histone deacetylases (HDACs) are central epigenetic regulators of macrophage-polarization. We hypothesized that HDAC3 inhibition suppresses the pro-inflammatory macrophage phenotype (M1), promotes the anti-inflamma...

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Detalles Bibliográficos
Autores principales: Sanchez, Selien, Lemmens, Stefanie, Baeten, Paulien, Sommer, Daniela, Dooley, Dearbhaile, Hendrix, Sven, Gou Fabregas, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221838/
https://www.ncbi.nlm.nih.gov/pubmed/30429652
http://dx.doi.org/10.5607/en.2018.27.5.437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221838/
https://www.ncbi.nlm.nih.gov/pubmed/30429652
http://dx.doi.org/10.5607/en.2018.27.5.437

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