Isolation and Characterization of Human Monoclonal Antibodies That Recognize the Influenza A(H1N1)pdm09 Virus Hemagglutinin Receptor-Binding Site and Rarely Yield Escape Mutant Viruses

The influenza A virus rapidly mutates to escape from antibodies. Here, we isolated and characterized three human monoclonal antibodies (mAbs) that neutralize A(H1N1)pdm09 viruses. Generation of escape mutant viruses suggested that these antibodies recognized conserved residues of the receptor-bindin...

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Detalles Bibliográficos
Autores principales: Yasuhara, Atsuhiro, Yamayoshi, Seiya, Ito, Mutsumi, Kiso, Maki, Yamada, Shinya, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222141/
https://www.ncbi.nlm.nih.gov/pubmed/30443246
http://dx.doi.org/10.3389/fmicb.2018.02660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222141/
https://www.ncbi.nlm.nih.gov/pubmed/30443246
http://dx.doi.org/10.3389/fmicb.2018.02660

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