Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss

Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear...

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Detalles Bibliográficos
Autores principales: Chai, Tian, Zhao, Xiao-Bo, Wang, Wei-Feng, Qiang, Yin, Zhang, Xiao-Yun, Yang, Jun-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222358/
https://www.ncbi.nlm.nih.gov/pubmed/30332835
http://dx.doi.org/10.3390/molecules23102663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222358/
https://www.ncbi.nlm.nih.gov/pubmed/30332835
http://dx.doi.org/10.3390/molecules23102663

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