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Design, Synthesis of N-phenethyl Cinnamide Derivatives and Their Biological Activities for the Treatment of Alzheimer’s Disease: Antioxidant, Beta-amyloid Disaggregating and Rescue Effects on Memory Loss
Gx-50 is a bioactive compound for the treatment of Alzheimer’s disease (AD) found in Sichuan pepper (Zanthoxylum bungeanum). In order to find a stronger anti-AD lead compound, 20 gx-50 (1–20) analogs have been designed and synthesized, and their molecular structures were determined based on nuclear...
Autores principales: | Chai, Tian, Zhao, Xiao-Bo, Wang, Wei-Feng, Qiang, Yin, Zhang, Xiao-Yun, Yang, Jun-Li |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222358/ https://www.ncbi.nlm.nih.gov/pubmed/30332835 http://dx.doi.org/10.3390/molecules23102663 |
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