A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells

In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities. Of these eight compounds, (E)-3-(2,4-dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one (1c) showed strong competitive inhibit...

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Detalles Bibliográficos
Autores principales: Kim, Chang Seok, Noh, Sang Gyun, Park, Yujin, Kang, Dongwan, Chun, Pusoon, Chung, Hae Young, Jung, Hee Jin, Moon, Hyung Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222382/
https://www.ncbi.nlm.nih.gov/pubmed/30360412
http://dx.doi.org/10.3390/molecules23102725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222382/
https://www.ncbi.nlm.nih.gov/pubmed/30360412
http://dx.doi.org/10.3390/molecules23102725

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