A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety

G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of drug-like properties and selectivity in order to reac...

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Detalles Bibliográficos
Autores principales: Tassinari, Martina, Lena, Alberto, Butovskaya, Elena, Pirota, Valentina, Nadai, Matteo, Freccero, Mauro, Doria, Filippo, Richter, Sara N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222391/
https://www.ncbi.nlm.nih.gov/pubmed/30060461
http://dx.doi.org/10.3390/molecules23081874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222391/
https://www.ncbi.nlm.nih.gov/pubmed/30060461
http://dx.doi.org/10.3390/molecules23081874

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