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A Fragment-Based Approach for the Development of G-Quadruplex Ligands: Role of the Amidoxime Moiety
G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of drug-like properties and selectivity in order to reac...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222391/ https://www.ncbi.nlm.nih.gov/pubmed/30060461 http://dx.doi.org/10.3390/molecules23081874 |