Design, Synthesis and Docking Studies of Novel Macrocyclic Pentapeptides as Anticancer Multi-Targeted Kinase Inhibitors

A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material. Structures of the newly synthesized compounds were established by IR, (1)H and (13)C-NMR, and MS spectral data and elemental an...

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Detalles Bibliográficos
Autores principales: Amr, Abd El-Galil E., Abo-Ghalia, Mohamed H., Moustafa, Gaber O., Al-Omar, Mohamed A., Nossier, Eman S., Elsayed, Elsayed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222410/
https://www.ncbi.nlm.nih.gov/pubmed/30241374
http://dx.doi.org/10.3390/molecules23102416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222410/
https://www.ncbi.nlm.nih.gov/pubmed/30241374
http://dx.doi.org/10.3390/molecules23102416

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