Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes

Genetic code expansion has largely relied on two types of the tRNA—aminoacyl-tRNA synthetase pairs. One involves pyrrolysyl-tRNA synthetase (PylRS), which is used to incorporate various lysine derivatives into proteins. The widely used PylRS from Methanosarcinaceae comprises two distinct domains whi...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Atsushi, Iraha, Fumie, Ohtake, Kazumasa, Sakamoto, Kensaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222415/
https://www.ncbi.nlm.nih.gov/pubmed/30261594
http://dx.doi.org/10.3390/molecules23102460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222415/
https://www.ncbi.nlm.nih.gov/pubmed/30261594
http://dx.doi.org/10.3390/molecules23102460

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