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Pyrrolysyl-tRNA Synthetase with a Unique Architecture Enhances the Availability of Lysine Derivatives in Synthetic Genetic Codes

Genetic code expansion has largely relied on two types of the tRNA—aminoacyl-tRNA synthetase pairs. One involves pyrrolysyl-tRNA synthetase (PylRS), which is used to incorporate various lysine derivatives into proteins. The widely used PylRS from Methanosarcinaceae comprises two distinct domains whi...

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Detalles Bibliográficos
Autores principales:	Yamaguchi, Atsushi, Iraha, Fumie, Ohtake, Kazumasa, Sakamoto, Kensaku
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222415/ https://www.ncbi.nlm.nih.gov/pubmed/30261594 http://dx.doi.org/10.3390/molecules23102460

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