Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo

This study focuses on the design, synthesis, biological evaluation, and computer-aided structure-activity relationship (SAR) analysis for a novel group of aromatic triazine-methylpiperazines, with an hydantoin spacer between 1,3,5-traizine and the aromatic fragment. New compounds were synthesized an...

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Detalles Bibliográficos
Autores principales: Kurczab, Rafał, Ali, Wesam, Łażewska, Dorota, Kotańska, Magdalena, Jastrzębska-Więsek, Magdalena, Satała, Grzegorz, Więcek, Małgorzata, Lubelska, Annamaria, Latacz, Gniewomir, Partyka, Anna, Starek, Małgorzata, Dąbrowska, Monika, Wesołowska, Anna, Jacob, Claus, Kieć-Kononowicz, Katarzyna, Handzlik, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222450/
https://www.ncbi.nlm.nih.gov/pubmed/30282913
http://dx.doi.org/10.3390/molecules23102529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222450/
https://www.ncbi.nlm.nih.gov/pubmed/30282913
http://dx.doi.org/10.3390/molecules23102529

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