Cargando…

New 2-Oxoindolin Phosphonates as Novel Agents to Treat Cancer: A Green Synthesis and Molecular Modeling

The work reports the facile synthesis of novel α-aminophosphonate derivatives coupled with indole-2,3-dione moieties, namely the diethyl(substituted phenyl/heteroaryl)(2-(2-oxoindolin-3-ylidene)hydrazinyl)methylphosphonates derivatives 4(a–n). One-pot three component Kabachnik-Fields reactions were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tiwari, Shailee V., Sharif, Nawaz S., Gajare, Rekha I., Vazquez, Julio A. Seijas, Sangshetti, Jaiprakash N., Damale, Manoj D., Nikalje, Anna Pratima G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222476/ https://www.ncbi.nlm.nih.gov/pubmed/30096835 http://dx.doi.org/10.3390/molecules23081981

Ejemplares similares

Ionic Liquid-Catalyzed Green Protocol for Multi-Component Synthesis of Dihydropyrano[2,3-c]pyrazoles as Potential Anticancer Scaffolds
por: Nimbalkar, Urja D., et al.
Publicado: (2017)

Ultrasound Assisted Synthesis of 4-(Benzyloxy)-N-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl) Benzamide as Challenging Anti-Tubercular Scaffold
por: Nimbalkar, Urja D., et al.
Publicado: (2018)

Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones
por: Nimbalkar, Urja D., et al.
Publicado: (2016)

Ultrasound Mediated One-Pot, Three Component Synthesis, Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-8,8a-dihydro-7H-(1,3,4)thiadiazolo(3,2-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents
por: Tiwari, Shailee V., et al.
Publicado: (2016)

Facile Synthesis of Novel Coumarin Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study, ADMET Prediction and Toxicity Study
por: Tiwari, Shailee V., et al.
Publicado: (2017)

Ionic Liquid-Promoted Synthesis of Novel Chromone-Pyrimidine Coupled Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study and Toxicity Study
por: Tiwari, Shailee V., et al.
Publicado: (2018)

Microwave-Assisted Facile Synthesis, Anticancer Evaluation and Docking Study of N-((5-(Substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) Benzamide Derivatives
por: Tiwari, Shailee V., et al.
Publicado: (2017)

Pharmacoinformatics approaches to identify potential hits against tetraacyldisaccharide 4′-kinase (LpxK) of Pseudomonas aeruginosa
por: Damale, Manoj G., et al.
Publicado: (2020)

New N-phenylacetamide-incorporated 1,2,3-triazoles: [Et(3)NH][OAc]-mediated efficient synthesis and biological evaluation
por: Akolkar, Satish V., et al.
Publicado: (2019)

Design, synthesis and evaluation of novel 2-oxoindoline-based acetohydrazides as antitumor agents
por: Dung, Do T. M., et al.
Publicado: (2022)

Click chemistry inspired syntheses of new amide linked 1,2,3-triazoles from naphthols: biological evaluation and in silico computational study
por: Akolkar, Satish V., et al.
Publicado: (2023)

Molecular docking, pharmacophore based virtual screening and molecular dynamics studies towards the identification of potential leads for the management of H. pylori
por: Damale, Manoj G., et al.
Publicado: (2019)

Efficient one-pot synthesis, molecular docking and in silico ADME prediction of bis-(4-hydroxycoumarin-3-yl) methane derivatives as antileishmanial agents
por: Zaheer, Zahid, et al.
Publicado: (2015)

Extraction and Physicochemical Characterization of Chitin Derived from the Asian Hornet, Vespa velutina Lepeletier 1836 (Hym.: Vespidae)
por: Feás, Xesús, et al.
Publicado: (2020)

Structure-Based Site of Metabolism (SOM) Prediction of Ligand for CYP3A4 Enzyme: Comparison of Glide XP and Induced Fit Docking (IFD)
por: Lokwani, Deepak K., et al.
Publicado: (2020)

Electro-organic green synthesis of dicyano-2-(2-oxoindolin-3-ylidene) malononitriles using molecular iodine as catalyst
por: Verma, Neetu, et al.
Publicado: (2023)

2-Oxoindolin-3-yl acetate
por: Deng, Qiang
Publicado: (2011)

Synthesis, Cytotoxicity, DNA Binding and Apoptosis of Rhein-Phosphonate Derivatives as Antitumor Agents
por: Ye, Man-Yi, et al.
Publicado: (2013)

Direct Synthesis of Phosphonates and α-Amino-phosphonates from 1,3-Benzoxazines
por: Salgado-Escobar, Oscar, et al.
Publicado: (2019)

One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
por: Aksenov, Nicolai A., et al.
Publicado: (2022)

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
por: Danne, Ashruba B., et al.
Publicado: (2021)

4-(3-Fluorophenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Ramzan, Muhammad, et al.
Publicado: (2010)

4-(3-Iodophenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Pervez, Humayun, et al.
Publicado: (2010)

Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs
por: Pradere, Ugo, et al.
Publicado: (2014)

4-(3-Nitrophenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Pervez, Humayun, et al.
Publicado: (2010)

4-(3-Methoxyphenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Pervez, Humayun, et al.
Publicado: (2010)

4-(2-Fluorophenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Pervez, Humayun, et al.
Publicado: (2010)

4-(2-Ethylphenyl)-1-(2-oxoindolin-3-ylidene)thiosemicarbazide
por: Pervez, Humayun, et al.
Publicado: (2010)

Rapid Construction of Substituted Dihydrothiophene Ureidoformamides at Room Temperature Using Diisopropyl Ethyl Ammonium Acetate: A Green Perspective
por: Jadhav, Chetan K., et al.
Publicado: (2020)

Harnessing phosphonate antibiotics argolaphos biosynthesis enables a synthetic biology-based green synthesis of glyphosate
por: Chu, Leixia, et al.
Publicado: (2022)

Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity
por: Chrobak, Elwira, et al.
Publicado: (2016)

Copper-Promoted Cross-Coupling Reactions for the Synthesis of Aryl(difluoromethyl)phosphonates Using Trimethylsilyl(difluoromethyl)phosphonate
por: Komoda, Kazuki, et al.
Publicado: (2018)

Synthesis of Functionalized Diethyl(pyrrolidin-2-yl)phosphonate and Diethyl(5-oxopyrrolidin-2-yl)phosphonate
por: Głowacka, Iwona E., et al.
Publicado: (2021)

2-Azahetaryl-2-(oxoindolin-2-ylidene)acetonitriles as Colorimetric Probes for Zn: Synthesis and Optical Properties
por: Shcherban, Vladyslav V., et al.
Publicado: (2022)

1-(5-Nitro-2-oxoindolin-3-ylidene)-4-o-tolylthiosemicarbazide methanol monosolvate
por: Pervez, Humayun, et al.
Publicado: (2009)

1-(2-Oxoindolin-3-ylidene)-4-[2-(trifluoromethyl)phenyl]thiosemicarbazide
por: Ramzan, Muhammad, et al.
Publicado: (2010)

A Sustainable and Efficient Synthesis of Benzyl Phosphonates Using PEG/KI Catalytic System
por: Disale, Shamrao, et al.
Publicado: (2016)

1-(2-Oxoindolin-3-ylidene)-4-[2-(trifluoromethoxy)phenyl]thiosemicarbazide
por: Ramzan, Muhammad, et al.
Publicado: (2010)

Synthesis of phosphonate and phostone analogues of ribose-1-phosphates
por: Nasomjai, Pitak, et al.
Publicado: (2009)

Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates
por: Ford, Alan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5rkm8kjt4q5et5p5r4kuhmvqd0