Synthesis and Evaluation of Novel Ligustrazine Derivatives as Multi-Targeted Inhibitors for the Treatment of Alzheimer’s Disease

A series of novel ligustrazine derivatives 8a–r were designed, synthesized, and evaluated as multi-targeted inhibitors for anti-Alzheimer’s disease (AD) drug discovery. The results showed that most of them exhibited a potent ability to inhibit both ChEs, with a high selectivity towards AChE. In part...

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Detalles Bibliográficos
Autores principales: Wu, Wenhao, Liang, Xintong, Xie, Guoquan, Chen, Langdi, Liu, Weixiong, Luo, Guolin, Zhang, Peiquan, Yu, Lihong, Zheng, Xuehua, Ji, Hong, Zhang, Chao, Yi, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222487/
https://www.ncbi.nlm.nih.gov/pubmed/30301153
http://dx.doi.org/10.3390/molecules23102540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222487/
https://www.ncbi.nlm.nih.gov/pubmed/30301153
http://dx.doi.org/10.3390/molecules23102540

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