Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells

Reversine is a potent antitumor 2,6-diamino-substituted purine acting as an Aurora kinases inhibitor and interfering with cancer cell cycle progression. In this study we describe three reversine-related molecules, designed by docking calculation, that present structural modifications in the diamino...

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Detalles Bibliográficos
Autores principales: Bosco, Bartolomeo, Defant, Andrea, Messina, Andrea, Incitti, Tania, Sighel, Denise, Bozza, Angela, Ciribilli, Yari, Inga, Alberto, Casarosa, Simona, Mancini, Ines
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222518/
https://www.ncbi.nlm.nih.gov/pubmed/30103421
http://dx.doi.org/10.3390/molecules23081996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222518/
https://www.ncbi.nlm.nih.gov/pubmed/30103421
http://dx.doi.org/10.3390/molecules23081996

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