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Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells

Reversine is a potent antitumor 2,6-diamino-substituted purine acting as an Aurora kinases inhibitor and interfering with cancer cell cycle progression. In this study we describe three reversine-related molecules, designed by docking calculation, that present structural modifications in the diamino...

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Detalles Bibliográficos
Autores principales:	Bosco, Bartolomeo, Defant, Andrea, Messina, Andrea, Incitti, Tania, Sighel, Denise, Bozza, Angela, Ciribilli, Yari, Inga, Alberto, Casarosa, Simona, Mancini, Ines
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222518/ https://www.ncbi.nlm.nih.gov/pubmed/30103421 http://dx.doi.org/10.3390/molecules23081996

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