Synthesis and Evolution of Berberine Derivatives as a New Class of Antiviral Agents against Enterovirus 71 through the MEK/ERK Pathway and Autophagy

Taking berberine (BBR) as the lead, 23 new BBR derivatives were synthesized and examined for their antiviral activities against four different genotype enterovirus 71 (EV71) strains with a cytopathic effect (CPE) assay. Structure-activity relationship (SAR) studies indicated that introduction of a s...

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Detalles Bibliográficos
Autores principales: Wang, Yan-Xiang, Yang, Lu, Wang, Hui-Qiang, Zhao, Xiao-Qiang, Liu, Ting, Li, Ying-Hong, Zeng, Qing-Xuan, Li, Yu-Huan, Song, Dan-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222558/
https://www.ncbi.nlm.nih.gov/pubmed/30127288
http://dx.doi.org/10.3390/molecules23082084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222558/
https://www.ncbi.nlm.nih.gov/pubmed/30127288
http://dx.doi.org/10.3390/molecules23082084

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