Cargando…

The Effect of Absorption-Enhancement and the Mechanism of the PAMAM Dendrimer on Poorly Absorbable Drugs

The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0–G3) and concentrations (0.1–1.0%) on the pulmonary absorption of macromolecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Juan, Li, Nannan, Gao, Yaochun, Li, Nan, Guo, Yifei, Liu, Haitao, Chen, Xi, Zhu, Chunyan, Dong, Zhengqi, Yamamoto, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222674/ https://www.ncbi.nlm.nih.gov/pubmed/30103462 http://dx.doi.org/10.3390/molecules23082001

Ejemplares similares

Mechanistic Studies on the Absorption-Enhancing Effects of Gemini Surfactant on the Intestinal Absorption of Poorly Absorbed Hydrophilic Drugs in Rats
por: Alama, Tammam, et al.
Publicado: (2019)

Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
por: Pyreddy, Suneela, et al.
Publicado: (2014)

Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies
por: Konopka, Malgorzata, et al.
Publicado: (2018)

High Fluorescent Porphyrin-PAMAM-Fluorene Dendrimers
por: Garfias-Gonzalez, Karla I., et al.
Publicado: (2015)

Acetylation of PAMAM dendrimers for cellular delivery of siRNA
por: Waite, Carolyn L, et al.
Publicado: (2009)

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors
por: Jones, David E, et al.
Publicado: (2015)

New Advances in General Biomedical Applications of PAMAM Dendrimers
por: de Araújo, Renan Vinicius, et al.
Publicado: (2018)

Hydrogel of Ketoconazole and PAMAM Dendrimers: Formulation and Antifungal Activity
por: Winnicka, Katarzyna, et al.
Publicado: (2012)

In Vitro Evaluation of Third Generation PAMAM Dendrimer Conjugates
por: Najlah, Mohammad, et al.
Publicado: (2017)

Twenty Years of Research on Cyclodextrin Conjugates with PAMAM Dendrimers
por: Arima, Hidetoshi
Publicado: (2021)

Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate
por: Filipowicz, A, et al.
Publicado: (2012)

Diffusion NMR Study of Generation-Five PAMAM Dendrimer Materials
por: van Dongen, Mallory A., et al.
Publicado: (2014)

Cationic PAMAM Dendrimers as Pore-Blocking Binary Toxin Inhibitors
por: Förstner, Philip, et al.
Publicado: (2014)

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
por: Svenningsen, Søren Wedel, et al.
Publicado: (2020)

Remineralization of dentine tubules induced by phosphate-terminated PAMAM dendrimers
por: Wen, Yajie, et al.
Publicado: (2020)

Synthesis and Activity of Ionic Antioxidant-Functionalized PAMAMs and PPIs Dendrimers
por: Bacha, Katia, et al.
Publicado: (2022)

Immobilization of Alcalase on Silica Supports Modified with Carbosilane and PAMAM Dendrimers
por: Sánchez-Milla, María, et al.
Publicado: (2022)

Polyamidoamine (PAMAM) Dendrimers Modified with Cathepsin-B Cleavable Oligopeptides for Enhanced Gene Delivery
por: Lee, Seulgi, et al.
Publicado: (2017)

Selective cytotoxicity of PAMAM G5 core–PAMAM G2.5 shell tecto-dendrimers on melanoma cells
por: Schilrreff, Priscila, et al.
Publicado: (2012)

Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles
por: Kurokawa, Yoshika, et al.
Publicado: (2017)

Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish
por: Pryor, Joseph B, et al.
Publicado: (2014)

Photosensitizer and peptide-conjugated PAMAM dendrimer for targeted in vivo photodynamic therapy
por: Narsireddy, Amreddy, et al.
Publicado: (2015)

Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization
por: Vidal, Felipe, et al.
Publicado: (2017)

The Effect of PAMAM Dendrimers on the Antibacterial Activity of Antibiotics with Different Water Solubility
por: Winnicka, Katarzyna, et al.
Publicado: (2013)

PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding
por: Mostovaya, Olga, et al.
Publicado: (2021)

An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications
por: Lesniak, Wojciech G., et al.
Publicado: (2022)

DNA Condensation by Peptide-Conjugated PAMAM Dendrimers. Influence of Peptide Charge
por: Dannert, Corinna, et al.
Publicado: (2023)

Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System
por: Vu, Minh Thanh, et al.
Publicado: (2019)

Molecular Mechanisms of Antitumor Activity of PAMAM Dendrimer Conjugates with Anticancer Drugs and a Monoclonal Antibody
por: Marcinkowska, Monika, et al.
Publicado: (2019)

Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death
por: Li, Yubin, et al.
Publicado: (2015)

Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer
por: Kulhari, Hitesh, et al.
Publicado: (2016)

Molecular dynamics simulations in drug delivery research: Calcium chelation of G3.5 PAMAM dendrimers
por: Jones, David E., et al.
Publicado: (2016)

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review
por: Fana, Michael, et al.
Publicado: (2020)

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA
por: Arima, Hidetoshi, et al.
Publicado: (2009)

Role of Counterions in Constant-pH Molecular Dynamics Simulations of PAMAM Dendrimers
por: Reis, Pedro B. P. S., et al.
Publicado: (2018)

8-Hydroxyquinoline Dansylates Modified with PAMAM Dendrimer as Fluorescent Fe(3+ )Sensors
por: Zhang, Qi, et al.
Publicado: (2010)

Anticancer Activity of Water-Soluble Olsalazine-PAMAM-Dendrimer-Salicylic Acid-Conjugates
por: Cortez-Maya, Sandra, et al.
Publicado: (2019)

Nanoscale Investigation of Generation 1 PAMAM Dendrimers Interaction with a Protein Nanopore
por: Asandei, Alina, et al.
Publicado: (2017)

Detection of dengue using PAMAM dendrimer integrated tapered optical fiber sensor
por: Mustapha Kamil, Yasmin, et al.
Publicado: (2019)

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy
por: Tarach, Piotr, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8njg5hhhh400mn5775a2umm20h