Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity

1,3-Dipolar cycloaddition of N-methyl C-(diethoxyphosphoryl) nitrone to N3-substituted 6-bromo-2-vinyl-3H-quinazolin-4-ones gave (3-diethoxyphosphoryl) isoxazolidines substituted at C5 with quinazolinones modified at N3. All isoxazolidine cycloadducts were screened for antiviral activity against a b...

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Detalles Bibliográficos
Autores principales: Grabkowska-Drużyc, Magdalena, Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Piotrowska, Dorota G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222691/
https://www.ncbi.nlm.nih.gov/pubmed/30060562
http://dx.doi.org/10.3390/molecules23081889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222691/
https://www.ncbi.nlm.nih.gov/pubmed/30060562
http://dx.doi.org/10.3390/molecules23081889

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