A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the development of improved anticancer treatments, as its inhibition may enhance the therapeutic effect of topoisomerase 1 poisons. Here, we report a...

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Detalles Bibliográficos
Autores principales: Li-Zhulanov, Nikolai S., Zakharenko, Alexandra L., Chepanova, Arina A., Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin P., Salakhutdinov, Nariman F., Reynisson, Jóhannes, Leung, Ivanhoe K. H., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222798/
https://www.ncbi.nlm.nih.gov/pubmed/30261631
http://dx.doi.org/10.3390/molecules23102468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222798/
https://www.ncbi.nlm.nih.gov/pubmed/30261631
http://dx.doi.org/10.3390/molecules23102468

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