Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs

As part of our initial efforts into developing a tumor-targeting therapy, C-10 substituted derivatives of a camptothecin analog (SN-38) have been synthesized (2-, 3- and 4-nitrobenzyl) for use as potential hypoxia-activated prodrugs and evaluated for their cytotoxicity, topoisomerase I inhibition an...

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Detalles Bibliográficos
Autores principales: Liang, Dinghua, Wu, Xing, Hasinoff, Brian B., Herbert, David E., Tranmer, Geoffrey K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222813/
https://www.ncbi.nlm.nih.gov/pubmed/30111719
http://dx.doi.org/10.3390/molecules23082041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222813/
https://www.ncbi.nlm.nih.gov/pubmed/30111719
http://dx.doi.org/10.3390/molecules23082041

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