KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes

Xanthine-based KMUP-1 was shown to inhibit phosphodiesterases (PDEs) and modulate G-protein coupled receptors (GPCRs) to lower hyperlipidemia and body weight. This study further investigated whether KMUP-1 affects adipogenesis and lipolysis in 3T3-L1 preadipocytes. KMUP-1 (1–40 µM) concentration-dep...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Chung-Pin, Chau, Pei-Chun, Chang, Chain-Ting, An, Li-Mei, Yeh, Jwu-Lai, Chen, Ing-Jun, Wu, Bin-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222827/
https://www.ncbi.nlm.nih.gov/pubmed/30249030
http://dx.doi.org/10.3390/molecules23102433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222827/
https://www.ncbi.nlm.nih.gov/pubmed/30249030
http://dx.doi.org/10.3390/molecules23102433

Ejemplares similares