Cargando…
KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes
Xanthine-based KMUP-1 was shown to inhibit phosphodiesterases (PDEs) and modulate G-protein coupled receptors (GPCRs) to lower hyperlipidemia and body weight. This study further investigated whether KMUP-1 affects adipogenesis and lipolysis in 3T3-L1 preadipocytes. KMUP-1 (1–40 µM) concentration-dep...
Autores principales: | Liu, Chung-Pin, Chau, Pei-Chun, Chang, Chain-Ting, An, Li-Mei, Yeh, Jwu-Lai, Chen, Ing-Jun, Wu, Bin-Nan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222827/ https://www.ncbi.nlm.nih.gov/pubmed/30249030 http://dx.doi.org/10.3390/molecules23102433 |
Ejemplares similares
-
Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss
por: Kuo, Kung-Kai, et al.
Publicado: (2015) -
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice
por: Wu, Bin-Nan, et al.
Publicado: (2016) -
Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway
por: Li, Zhengming, et al.
Publicado: (2019) -
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
por: Lee, Meng-Luen, et al.
Publicado: (2019) -
KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2013)