Cargando…

KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes

Xanthine-based KMUP-1 was shown to inhibit phosphodiesterases (PDEs) and modulate G-protein coupled receptors (GPCRs) to lower hyperlipidemia and body weight. This study further investigated whether KMUP-1 affects adipogenesis and lipolysis in 3T3-L1 preadipocytes. KMUP-1 (1–40 µM) concentration-dep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Chung-Pin, Chau, Pei-Chun, Chang, Chain-Ting, An, Li-Mei, Yeh, Jwu-Lai, Chen, Ing-Jun, Wu, Bin-Nan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222827/ https://www.ncbi.nlm.nih.gov/pubmed/30249030 http://dx.doi.org/10.3390/molecules23102433

Ejemplares similares

Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss
por: Kuo, Kung-Kai, et al.
Publicado: (2015)

Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice
por: Wu, Bin-Nan, et al.
Publicado: (2016)

Effects of liraglutide on lipolysis and the AC3/PKA/HSL pathway
por: Li, Zhengming, et al.
Publicado: (2019)

KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
por: Lee, Meng-Luen, et al.
Publicado: (2019)

KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2013)

KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2015)

The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K(+)-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries
por: Dai, Zen-Kong, et al.
Publicado: (2015)

Xanthine Derivative KMUP-1 Attenuates Experimental Periodontitis by Reducing Osteoclast Differentiation and Inflammation
por: Kuo, Cheng-Hsiang, et al.
Publicado: (2022)

Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes
por: Abe, Tomoki, et al.
Publicado: (2023)

The Mechanism of Ciliary Stimulation by Acetylcholine: Roles of Calcium, PKA, and PKG
por: Zagoory, Orna, et al.
Publicado: (2002)

In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis
por: Huang, Shang-En, et al.
Publicado: (2021)

Data supporting the effects of xanthine derivative KMUP-3 on vascular smooth muscle cell calcification and abdominal aortic aneurysm in mice
por: Lai, Chao-Han, et al.
Publicado: (2020)

BK(Ca) Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia
por: Cheng, Kuang-I, et al.
Publicado: (2021)

Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes
por: Eseberri, Itziar, et al.
Publicado: (2019)

Transforming PKA into PKG – a structure-function approach to understand cyclic nucleotide selectivity
por: Lorenz, Robin, et al.
Publicado: (2013)

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway
por: Zheng, Xifen, et al.
Publicado: (2023)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor
por: Jewell, Jenna L, et al.
Publicado: (2019)

FGF11 influences 3T3‐L1 preadipocyte differentiation by modulating the expression of PPARγ regulators
por: Lee, Kyeong Won, et al.
Publicado: (2019)

Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway
por: Park, Tae-Jun, et al.
Publicado: (2021)

A Study of the Regulatory Mechanism of the CB1/PPARγ2/PLIN1/HSL Pathway for Fat Metabolism in Cattle
por: Liu, Ruili, et al.
Publicado: (2021)

NPRC deletion attenuates cardiac fibrosis in diabetic mice by activating PKA/PKG and inhibiting TGF-β1/Smad pathways
por: Meng, Linlin, et al.
Publicado: (2023)

The HslV Protease from Leishmania major and Its Activation by C-terminal HslU Peptides
por: Kebe, Ndeye Mathy, et al.
Publicado: (2019)

Thyroid-Stimulating Hormone Inhibits Adipose Triglyceride Lipase in 3T3-L1 Adipocytes through the PKA Pathway
por: Jiang, Dongqing, et al.
Publicado: (2015)

An Overview of Hormone-Sensitive Lipase (HSL)
por: Althaher, Arwa R.
Publicado: (2022)

Chlorogenic Acid Functions as a Novel Agonist of PPARγ2 during the Differentiation of Mouse 3T3-L1 Preadipocytes
por: Peng, Shu-guang, et al.
Publicado: (2018)

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
por: Gidon, Alexandre, et al.
Publicado: (2014)

Isoimperatorin enhances 3T3-L1 preadipocyte differentiation by regulating PPARγ and C/EBPα through the Akt signaling pathway
por: Jiang, Tiantuan, et al.
Publicado: (2019)

Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this
por: Jin, Shan-Xue, et al.
Publicado: (2022)

Human Single-chain Variable Fragments Neutralize Pseudomonas aeruginosa Quorum Sensing Molecule, 3O-C12-HSL, and Prevent Cells From the HSL-mediated Apoptosis
por: Santajit, Sirijan, et al.
Publicado: (2020)

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3
por: Rhodes, Jack, et al.
Publicado: (2022)

Organelle relationships in cultured 3T3-L1 preadipocytes
Publicado: (1980)

Cistanche promotes the adipogenesis of 3T3-L1 preadipocytes
por: Zhang, Ping, et al.
Publicado: (2022)

Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa
por: Zeng, Jianming, et al.
Publicado: (2016)

Twist 1 regulates the expression of PPARγ during hormone-induced 3T3-L1 preadipocyte differentiation: a possible role in obesity and associated diseases
por: Ma, Wanshan, et al.
Publicado: (2014)

Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways
por: Wang, Li, et al.
Publicado: (2017)

Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways
por: Lee, Mei-Yueh, et al.
Publicado: (2016)

PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3K/AKT and cGMP/PKG Signaling
por: Zhang, Qinghui, et al.
Publicado: (2018)

DNA replication checkpoint control of Wee1 stability by vertebrate Hsl7
por: Yamada, Ayumi, et al.
Publicado: (2004)

Update on the synergistic effect of HSL and insulin in the treatment of metabolic disorders
por: Lan, Yu-Long, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i3brmbat1nhkok9113s6mtonib