Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties

To investigate the amino acid transporter-based prodrug anticancer strategy further, several amino acid-conjugated amide gemcitabine prodrugs were synthesized to target amino acid transporters in pancreatic cancer cells. The structures of the synthesized amino acid-conjugated prodrugs were confirmed...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Sungwoo, Fang, Zhenghuan, Jung, Hoi-Yun, Yoon, Jin-Ha, Hong, Soon-Sun, Maeng, Han-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222828/
https://www.ncbi.nlm.nih.gov/pubmed/30314360
http://dx.doi.org/10.3390/molecules23102608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222828/
https://www.ncbi.nlm.nih.gov/pubmed/30314360
http://dx.doi.org/10.3390/molecules23102608

Ejemplares similares