Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

The entry of HIV-1 into permissible cells remains an extremely attractive and underexploited therapeutic intervention point. We have previously demonstrated the ability to extend the chemotypes available for optimization in the entry inhibitor class using computational means. Here, we continue this...

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Detalles Bibliográficos
Autores principales: Meuser, Megan E., Murphy, Michael B., Rashad, Adel A., Cocklin, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222832/
https://www.ncbi.nlm.nih.gov/pubmed/30081466
http://dx.doi.org/10.3390/molecules23081940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222832/
https://www.ncbi.nlm.nih.gov/pubmed/30081466
http://dx.doi.org/10.3390/molecules23081940

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