Be Aware of Aggregators in the Search for Potential Human ecto-5′-Nucleotidase Inhibitors

Promiscuous inhibition due to aggregate formation has been recognized as a major concern in drug discovery campaigns. Here, we report some aggregators identified in a virtual screening (VS) protocol to search for inhibitors of human ecto-5′-nucleotidase (ecto-5′-NT/CD73), a promising target for seve...

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Detalles Bibliográficos
Autores principales: Viviani, Lucas G., Piccirillo, Erika, Cheffer, Arquimedes, de Rezende, Leandro, Ulrich, Henning, Carmona-Ribeiro, Ana Maria, Amaral, Antonia T.-do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222861/
https://www.ncbi.nlm.nih.gov/pubmed/30060466
http://dx.doi.org/10.3390/molecules23081876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222861/
https://www.ncbi.nlm.nih.gov/pubmed/30060466
http://dx.doi.org/10.3390/molecules23081876

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