Design and Synthesis of New Benzophenone Derivatives with In Vivo Anti-Inflammatory Activity through Dual Inhibition of Edema and Neutrophil Recruitment

A series of novel benzophenone derivatives containing a thiazole heterocyclic nucleus were designed by molecular hybridization. Molecular docking studies have demonstrated the inhibitory potential of the designed compounds against cyclooxygenase (COX) isoenzymes. These compounds were synthesized, ch...

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Detalles Bibliográficos
Autores principales: Januario, Jaqueline P., de Souza, Thiago B., Lavorato, Stefânia N., Maiolini, Tatiane C. S., Domingos, Olívia S., Baldim, João L., Folquitto, Laís R. S., Soares, Marisi G., Chagas-Paula, Daniela A., Dias, Danielle F., dos Santos, Marcelo H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222881/
https://www.ncbi.nlm.nih.gov/pubmed/30049981
http://dx.doi.org/10.3390/molecules23081859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222881/
https://www.ncbi.nlm.nih.gov/pubmed/30049981
http://dx.doi.org/10.3390/molecules23081859

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