Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assays were carried out against a diversity of protease...

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Detalles Bibliográficos
Autores principales: Salomon, Emmanuel, Schmitt, Marjorie, Marapaka, Anil Kumar, Stamogiannos, Athanasios, Revelant, Germain, Schmitt, Céline, Alavi, Sarah, Florent, Isabelle, Addlagatta, Anthony, Stratikos, Efstratios, Tarnus, Céline, Albrecht, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222927/
https://www.ncbi.nlm.nih.gov/pubmed/30314342
http://dx.doi.org/10.3390/molecules23102607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222927/
https://www.ncbi.nlm.nih.gov/pubmed/30314342
http://dx.doi.org/10.3390/molecules23102607

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