Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6

Parkinson’s disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson’s. We report that nicotine reduces the abundance of SIRT6 in neuronal culture...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicholatos, Justin W., Francisco, Adam B., Bender, Carolyn A., Yeh, Tiffany, Lugay, Fraz J., Salazar, Jairo E., Glorioso, Christin, Libert, Sergiy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223043/
https://www.ncbi.nlm.nih.gov/pubmed/30409187
http://dx.doi.org/10.1186/s40478-018-0625-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223043/
https://www.ncbi.nlm.nih.gov/pubmed/30409187
http://dx.doi.org/10.1186/s40478-018-0625-y

Ejemplares similares