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Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail
BACKGROUND: The pharmaceutical industry is in the midst of a productivity crisis and rates of translation from bench to bedside are dismal. Patients are being let down by the current system of drug discovery; of the several 1000 diseases that affect humans, only a minority have any approved treatmen...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223056/ https://www.ncbi.nlm.nih.gov/pubmed/30404629 http://dx.doi.org/10.1186/s12967-018-1678-1 |