A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

BACKGROUND: Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associated with axonal microtubules (MTs) in the brain, and in tauo...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Yao, Yuemang, Cornec, Anne-Sophie, Oukoloff, Killian, James, Michael J., Koivula, Pyry, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223064/
https://www.ncbi.nlm.nih.gov/pubmed/30404654
http://dx.doi.org/10.1186/s13024-018-0291-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223064/
https://www.ncbi.nlm.nih.gov/pubmed/30404654
http://dx.doi.org/10.1186/s13024-018-0291-3

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